Bloodmark

Debuff that can be applied to an enemy. On bosses this can be seen as this dark-red part of the healthbar:
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This bloodmark explodes by defeault after 5s when applied from your weapon or 4s if applied from lifesteal or if you deal what would be lethal damage it explodes instantly.
 
The timer keeps getting refreshed whenever you apply a new bloodmark stack though.
 
The damage a bloodmark does can be explained from this formula:
 
 
$$Bloodmark damage = (Player Level + 8) * 0.75 * (Damage multiplier) * (Bloodmark stacks)$$
 
 
It scales with level, damage multiplier and the amount of bloodmark stacks currently on the enemy.